Described are transdermal drug delivery compositions comprising amphetamine, methods of manufacturing transdermal drug delivery compositions comprising amphetamine, and therapeutic methods using transdermal drug delivery compositions comprising amphetamine, such as may be desired for achieving central nervous system stimulation, such as for the treatment of attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), or for the treatment of narcolepsy. In some embodiments, the compositions comprise an amount of polyurethane effective to control the presence of and/or prevent the formation of phenyl acetone in the compositions. The polyurethane may be present in a drug-containing polymer matrix or in a backing adjacent the drug-containing polymer matrix.本發明闡述包括安非他命(amphetamine)之經皮藥物輸送組合物；製造包括安非他命之經皮藥物輸送組合物之方法；及使用包括安非他命之經皮藥物輸送組合物之治療方法，例如可期望用於達成中樞神經系統刺激，例如用於治療注意力缺陷病症(ADD)、注意力缺陷多動病症(ADHD)或用於治療嗜睡症。在一些實施例中，該等組合物包含其含量可以控制該等組合物中苯基丙酮之存在及/或防止該等組合物中苯基丙酮之形成之聚胺基甲酸酯。該聚胺基甲酸酯可存在於含藥物聚合物基質中或毗鄰該含藥物聚合物基質之背襯中。
