The present invention is directed to a compound of Formula Ior a single isomer thereof where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.本發明係針對式I化合物或其單一異構物;其中該化合物係視情況為其藥學上可接受之鹽、水合物、溶劑合物或組合,此外為製備式I化合物之方法,及使用式I化合物以治療癌症之方法。