Han Lei;Dominic Man-Kit Lam;Olivia Yee-Yee Lam;Fong Wilson Lam
发明人:
Olivia Yee-Yee Lam,Dominic Man-Kit Lam,Han Lei,Fong Wilson Lam
申请号：
US15648863
公开号：
US10617751B2
申请日:
2017.07.13
申请国别(地区):
US
年份:
2020
代理人:
摘要：
In the invention described here, the approach is to formulate an edible vaccine based on N-terminal yeast surface display expression systems including S. cerevisiae EBY100/pYD5-VP28, S. cerevisiae EBY100/pYD5-VP28-VP24 and S. cerevisiae EBY100/pYD5-VP24 for preventing shrimps such as L. vannamei, P. monodon and M. rosenbergii species from white spot syndrome virus (WSSV) infection, suggesting that yeast surface display expression system expressing WSSV antigen has potential as a prophylactic treatment for WSSV in shrimps via oral vaccination. The technology developed in this patent application can also be used to produce edible (oral) vaccines for preventing and treating other infectious diseases in animals and human.
