The present invention relates to a composition for treating or preventing white spot syndrome virus (WSSV) infection comprising a polypeptide selected from the group consisting of shrimp chitin-binding protein, WSSV VP53A protein, fragments thereof, and combinations thereof and a carrier.本發明係關於一種治療或預防白點症病毒感染之組合物,其包括選自以下所組成之群之多肽:蝦幾丁結合蛋白、白點症病毒VP53A蛋白、其片段、以及上述之組合,以及載體。本發明之組合物可作為飼料。