Disclosed is a nanobody preparation system for administration through the internal and external epidermis of head and neck and internal epidermal layer of nasal cavity, comprising a specific nanobody having a biological activity and an antibody-drug carrier for improving the stability and tissue penetration of the nanobody. The drug carrier comprises one or more of a water-soluble macromolecular bio-saccharide gum substrate, polyvinyl alcohol, polyamino acid, glycerine, phospholipid, sodium carboxymethyl cellulose, collagen, and a hydrolase inhibitor.
