A novel thyroid like compounds of formula (I), wherein R1, R2, R3, R4 and Z are as defined in the specification, method for its preparation, composition and use thereof. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions including obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.本發明揭露一種新穎之式(I)類甲狀腺化合物、此化合物之製備方法、含此化合物之組成物、以及此化合物及組成物作為藥劑之用途，其中R1、R2、R3、R4及Z之定義如說明書所述。此外，式(I)之化合物對於甲狀腺受體的結合親和力極低，顯然對於甲狀腺素不會造成。本發明亦有關於此式(I)化合物的用途，其用來製作藥劑以治療各種不同病症，如肥胖、異常血脂症、代謝症候群及代謝症候群相關之併發症狀。；
