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PHENOXYPYRIDINYLAMIDE DERIVATIVES, AND THEIR USE IN TREATMENT OF PDE4-MEDIATED DISEASE STATES
专利权人:
ASTRAZENEKA AB
发明人:
EhNDRJuS Glen (GB),ЭНДРЮС Глен (GB),KOKS Rona Dzhejn (GB),КОКС Рона Джейн (GB),DE SAVI Kristofer (GB),ДЕ САВИ Кристофер (GB),MEGANI Premdzhi (GB),МЕГАНИ Премджи (GB),SANGANI Khitesh Dzhajantilal (GB),EHNDRJUS GLEN,ЭНДРЮС Глен,KOKS RONA DZHEJN,КОКС Рона Джейн,DE SAVI KRISTOFER,ДЕ САВИ Кристофер,MEGANI PREMDZHI,МЕГАНИ Премджи,SANGANI KHITESH DZHAJANTILAL,САНГАНИ Хитеш Джаянтилал,UORNER DANIEHL DZHON
申请号:
RU2010149496/04
公开号:
RU0002509077C2
申请日:
2009.05.26
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
FIELD: biotechnologies.SUBSTANCE: invention refers to a compound of formula (I):,where R1 represents NR7C(O)R8 or NR9R10; R2 represents hydrogen; R3 represents halogen; R4 represents hydrogen, halogen, cyano, hydroxy, C1-4alkyl, C1-4alkoxy, CF3, OCF3, C1-4alkylthio, S(O)(C1-4alkyl), S(O)2(C1-4alkyl), CO2H or CO2(C1-4alkyl); R5 represents C1-6alkyl (replaced with NR11R12 or heterocyclyl that represents nonaromatic 5-7-membered ring containing 1 or 2 heteroatoms independently chosen from a group containing nitrogen, oxygen or sulphur); R6 represents hydrogen, halogen, hydroxy, C1-4alkoxy, CO2H or C1-6alkyl (possibly replaced with NR15R16 group, morpholinyl or thiomorpholinyl); R7 represents hydrogen; R8 represents C3-6cycloalkyl (possibly replaced with NR24R25 group), phenyl or heteroaryl, which represents aromatic 5- or 6-membered ring containing 1 to 3 heteroatoms independently chosen from the group containing nitrogen, oxygen and sulphur, and which is probably condensed with one 6-membered aromatic or nonaromatic carbocyclic ring or with one 6-membered aromatic heterocyclic ring, where the above 6-membered aromatic heterocyclic ring includes 1 to 3 heteroatoms independently chosen from a group containing nitrogen, oxygen and sulphur; R9 represents hydrogen or C1-6alkyl (possibly replaced with pyrazolyl); R10 represents C1-6alkyl (possibly replaced with phenyl or heteroaryl group, which represents aromatic 5- or 6-membered ring containing 1 or 2 heteroatoms independently chosen from the group containing nitrogen, oxygen or sulphur, and which is possibly condensed with one 6-membered heterocyclic ring, where the above 6-membered aromatic heterocyclic ring contains 1 or 2 heteroatoms independently chosen from the group containing nitrogen, oxygen or sulphur; where the above phenyl and heteroaryl groups in R8, R9 and R10 are possibly independently replaced with the following group: halogen, hydroxy, C(O)R42, C1-6alkyl, C1-6hydroxyalkyl, C1-6halogenoalkyl, C1-6alkoxy(C1
来源网站:
中国工程科技知识中心
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