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Recombinant monoclonal antibody vNAR that neutralizes vascular endothelial growth factor (VEGF)
专利权人:
テラクロン アイディーエフ エセ エレ
发明人:
エロスア ポルトガル カロライナ,マタ ゴンザレス マリア テレサ,カマチョ ビレガス タニア アマンダ,オルギン ヒメネス アラセリ,リセア ナバッロ アレクセイ フェドロビシ,パニアグア ソリス ホルヘ フェルナンド
申请号:
JP2016562017
公开号:
JP6426198B2
申请日:
2014.04.17
申请国别(地区):
JP
年份:
2018
代理人:
摘要:
The present invention refers to the selection, isolation and purification of proteins belonging to variable regions named V H NAR or vNAR, originated from IgNAR-type immunoglobulins of elasmobranches with antigen receptor abilities. The clones from which they originate are named VEGFvNAR V32R and V 19; and the antibodies are named V32R and V19. Their amino acid sequences and tertiary structures were elucidated, and their ability to neutralize the vascular endothelial growth factor (VEGF) activity was determined. During the development of the invention these proteins were optimized for expression in a production model of E.coli at industrial level. The invention involves the use of these antibodies in general to treat conditions related to angiogenesis or neovascularization and in particular to treat neovascularization-related ophthalmic conditions by topical administration.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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