Levy, Stuart B.,Alekshun, Micheal N.,Podlogar, Brent,Ohemeng, Kwasi,Verma, Atul,Warchol, Tadeusz,Bhatia, Beena
申请号：
AU2011265525
公开号：
AU2011265525A1
申请日:
2011.12.23
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2011265525A120120202.pdf#####ABSTRACT Methods for identifying compound useful as anti-infectives that decrease 5 resistance, virulence, or growth of microbes are provided. In one embodiment, the method comprises contacting a microbial cell comprising: 1) a selectable marker under the control of a transcription factor responsive element and 2) a transcription factor, with a compound under conditions which allow interaction of the compound with the microbial cell； and measuring the ability of the compound to affect the growth or 10 survival of the niicrobial cell as an indication of whether the test compound modulates the activity of a transcription factor. 4l
