As for this invention, the NOV protein which is displayed with arrangement number 2 Or the fragment of the aforementioned protein which is stipulated by the fact that blood vessel new life obstruction activity is shown Or arrangement origin, or the description above of the arrangement number 2 which is stipulated by the fact that blood vessel new life obstruction activity is shown optional arrangement of the fragment origin which is defined Or in the fragment which is defined with arrangement or the description above of the arrangement number 2 which is stipulated by the fact that blood vessel new life obstruction activity is shown homologous optional arrangement It regards, the use of the protein for producing the medicine for remedy of sick condition where it includes, or features that it is constituted, needs the obstruction of endothelium multiplication or the sick condition which needs the obstruction of activation of the endothelium.本発明は、配列番号2で表されるNOVタンパク質;又は血管新生阻害活性を示すことで規定される前記タンパク質のフラグメント;又は血管新生阻害活性を示すことで規定される配列番号2の配列由来、又は前記定義されたフラグメント由来の任意の配列;又は血管新生阻害活性を示すことで規定される配列番号2の配列、又は前記で定義されたフラグメントに相同的な任意の配列;を含むか又は構成されることを特徴とする、内皮増殖の阻害を必要とする病態、又は内皮の活性化の阻害を必要とする病態の治療用薬剤の製造のための、タンパク質の使用に関する。
