VAN DEN BOSCH, LUDO,VAN OUTRYVE D'YDEWALLE, CONSTANTIN,ROBBERECHT, WIM
申请号：
CA2812855
公开号：
CA2812855C
申请日:
2011.10.06
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present application relates to diseases in the peripheral nervous system, particularly hereditary neuropathies, most particularly, Charcot-Marie-Tooth (CMT) disease. It is shown that this disease is associated with decreased acetylated tubulin levels, which can be overcome by inhibition of histone deacetylases (HDACs). Using HDAC inhibitors, it is shown herein that the symptoms of the CMT phenotype can be overcome both in vitro and in vivo. Also provided herein are two different mouse models of CMT disease.
