Ludo Van Den Bosch,Constantin Van Outryve d'Ydewalle,Wim Robberecht,Constantin Van Outryve dYdewalle
申请号：
US14335716
公开号：
US20140329849A1
申请日:
2014.07.18
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The disclosure relates to diseases in the peripheral nervous system, particularly hereditary neuropathies, such as Charcot-Marie-Tooth (CMT) disease. It is shown that this disease is associated with decreased acetylated tubulin levels, which can be overcome by inhibition of histone deacetylases (HDACs). Using HDAC inhibitors, it is shown herein that the symptoms of the CMT phenotype can be overcome both in vitro and in vivo. Also provided herein are two different mouse models of CMT disease.
