Van Den Bosch, Ludo,Van Outryve D'ydewalle, Constantin,Robberecht, Wim,Van Outryve Dydewalle, Constantin
申请号：
AU2011311531
公开号：
AU2011311531B2
申请日:
2011.10.06
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present application relates to diseases in the peripheral nervous system, particularly hereditary neuropathies, most particularly, Charcot-Marie-Tooth (CMT) disease. It is shown that this disease is associated with decreased acetylated tubulin levels, which can be overcome by inhibition of histone deacetylases (HDACs). Using HDAC inhibitors, it is shown herein that the symptoms of the CMT phenotype can be overcome both
