SEIDEL III, Ronald D.,CHAPARRO, Rodolfo J.,ROSS, John F.,LOW, Chee Meng
申请号：
AU2018327224
公开号：
AU2018327224A1
申请日:
2018.09.06
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present disclosure provides T-cell modulatory multimeric polypeptides ("T-Cell-MMPs") comprising an immunomodulatory polypeptide ("MOD") that may be selected to exhibit reduced binding affinity to a cognate co-immunomodulatory polypeptide ("Co-MOD") and locations for covalently attaching a molecule that can serve as an epitope, such as an epitope peptide. Once the epitope molecule is attached the resulting T-Cell-MMP-epitope conjugates are useful for modulating the activity of a T-cell by delivering immunomodulatory peptides, such as IL-2 or IL-2 variants that exhibit reduced binding affinity for IL-2R, to the T-cells in an epitope selective/specific manner, and accordingly, for modulating an immune response in an individual.
