Rudolf Kunze,Gerd Wallukat,Peter Rosenthal,Richard Straube
申请号：
US12735416
公开号：
US08455442B2
申请日:
2009.01.15
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A peptide having an ED50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular α1 loop 2 or β2 loop 1 of a human adrenoceptor wherein the antibodys binding to the epitope results in an increase of γ-secretase activity, an increased release of β-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the ED50 value is measured by bioassay.
