The Charlotte-Mecklenburg Hospital Authority d/b/a Carolinas Medical Center
发明人:
Yubo SUN,Edward N. Hanley
申请号：
US15469658
公开号：
US20170232013A1
申请日:
2017.03.27
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention is directed to a composition and associated method for the treatment of musculoskeletal related disorders and diseases. In particular, the present invention provides a class of citrate compounds that can be used to for the treatment of diseases/disorders characterized by the degeneration of musculoskeletal tissues including menisci, bone, articular cartilage, and soft tissues. Examples of suitable citrate and citrate analog compounds include citrates having the following base formula (I):where X may be one of the following:wherein Y, Y′, and Y″ are independently a citrate moiety, O, O—Y, OH, NH, NH—Y, R and R—Y, with R being an alkyl, alkyene, ester, aryl, or phenyl group having from 1 to 6 carbon atoms.
