MOKPO NATIONAL UNIVERSITY INDUSTRY-ACADEMIA COOPERATION GROUP
发明人:
OAK, Min Ho,옥민호,SONG, Su Young,송수영,PARK, Sin Hee,박신희,YOON, Jun Seong,윤준성
申请号：
KRKR2015/000385
公开号：
WO2015/108332A1
申请日:
2015.01.14
申请国别(地区):
WO
年份:
2015
代理人:
摘要：
The present invention relates to a composition containing a Quercus salicina extract for preventing and treating cardiovascular disease. Specifically, the Quercus salicina extract strongly activates endothelial type nitric oxide synthetase, which is a main factor of vascular protection together with antioxidative efficacy, and controls contraction and relaxation of vascular smooth muscle, thereby exhibiting a strong vascular relaxation effect, resulting in regulating blood pressure and improving vascular endothelial dysfunction, and thus the composition containing the same as an active ingredient can be favorably used as a pharmaceutical composition or functional health food for preventing and treating cardiovascular disease including endothelial dysfunction.La présente invention concerne une composition contenant un extrait de Quercus salicina pour prévenir et traiter une maladie cardiovasculaire. En particulier, lextrait de Quercus salicina active fortement la synthétase doxyde nitrique du type endothélial, qui est un facteur principal de protection vasculaire ayant une efficacité antioxydante, et commande la contraction et la relaxation de muscle lisse vasculaire, présentant ainsi un puissant effet de relaxation vasculaire, ce qui permet de réguler la tension sanguine et daméliorer une dysfonction endothéliale vasculaire, et la composition contenant lextrait comme principe actif peut ainsi être utilisée de façon favorable comme composition pharmaceutique ou aliment naturel et fonctionnel pour prévenir et traiter une maladie cardiovasculaire comprenant une dysfonction endothéliale.본 발명은 참가시나무 추출물을 포함하는 심혈관계 질환의 치료 및 예방을 위한 조성물에 관한 것으로서, 구체적으로 참가시나무 추출물은 항산화 효능과 함께 혈관보호의 주요 인자인 혈관내피세포형 산화질소 합성효소를 강력하게 활성화하는 동시에 혈관평활근 (vascular smooth muscle)의 수축과 이완을 조절하여 강력한 혈관이완 효과를 나타내어 혈압조절 및 혈관내피세포 기능장애 (endothelial dysfunction)를 개선시키므로, 이를 유효성분으로 함유하는 조성물은 혈관내피세포 기능장애를 포함하는 심혈관계 질환의 예방 및 치료를 위한 약학 조성물 또는 건강기능식품으로 유용하게 이용될 수 있다.
