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COMPOSITIONS AND METHODS OF REGULATING EXPRESSION OF COLLAGEN AND ACT OF SMOOTH MUSCLES BY SERPINE2
专利权人:
Сентокор Рисерч энд Дивелопмент, Инк. (US); Инк. (US);Файв Прайм Терапеутикс, Инк. (US);Файв Прайм Терапеутикс
发明人:
БРЕЙС Артур (US),САЛЛИВАН Кэтлин (US),ФАЙНЕР Джеффри (US),БОШ Элизабет (US),БОЙЛ Кэтлин (US),УОНГ Брайан (US),ПИРС Кристен (US),БХАВЕ Каумуди (US),ДАС Анук (US),ФАРРЕЛЛ Франсис (US),СИВАКУМАР Питчуман
申请号:
RU2011121042/10
公开号:
RU2011121042A
申请日:
2009.11.25
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A method of inhibiting the expression level of collagen 1A1 and / or α-smooth muscle actin α-actin in a human lung fibroblast cell exposed to SERPINE2 (a serine proteinase inhibitor 2), comprising introducing a SERPINE2 antagonist into a human lung fibroblast cell. The method according to claim 1, further comprising detecting a decrease in the expression of collagen 1A1 and smooth muscle α-actin in the lung fibroblast cell. The method of claim 1, wherein the lung fibroblast cell is exposed to TGF-β (transforming growth factor-β) prior to exposure to the antagonist. The method of claim 1, wherein the lung fibroblast cell is exposed to IL-13 (interleukin-13) prior to exposure to the antagonist. The method of claim 1, wherein the SERPINE2 antagonist is an antibody. The method of claim 5, wherein the antibody is a monoclonal antibody. The method of claim 1, wherein the SERPINE2 antagonist is an RNAi molecule (RNA interference). The method of claim 1, wherein the SERPINE2 antagonist is an antisense nucleic acid molecule. The method of claim 1, wherein the SERPINE2 antagonist is a peptide. The method of claim 1, wherein the SERPINE2 antagonist is a low molecular weight inhibitor of SERPINE2.11. The method of claim 1, wherein the expression levels of collagen 1A1 and smooth muscle α-actin are inhibited. The method according to claim 1, where the level of collagen 1A1.13 is inhibited. The method of claim 1, wherein the expression level of smooth muscle α-actin is inhibited. A method of inhibiting the formation of myofibroblasts from human lung fibroblast cells exposed to elevated levels of SERPINE2, comprising introducing a SERPINE2 antagonist into human fibroblast cells l1. Способ ингибирования уровня экспрессии коллагена 1А1 и/или α-актина гладких мышц в человеческой клетке-фибробласте легкого, подверженной воздействию SERPINE2 (ингибитор сериновой протеиназы 2), включающий введение антагониста SERPINE2 в человеческую клетку-фибробласт легкого.2. Способ по п.1, дополни
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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