Zwiazek pochodny 8-chinolinoksantyny i 8-izochinolinoksantyny, jego zastosowanie, kompozycja farmaceutyczna zawierajaca zwiazek oraz sposób wytwarzania zwiazku
BHALAY GURDIP,COLLINGWOOD STEPHEN PAUL,FAIRHURST ROBIN ALEC,GOMEZ SYLVIE FELICITE,NAEF RETO,SANDHAM DAVID ANDREW,SANDHAM DAVID AN
申请号：
PL35820501
公开号：
PL212407B1
申请日:
2001.04.05
申请国别(地区):
PL
年份:
2012
代理人:
摘要：
A compound of formula (I) in free or salt form, where R<；1 >；is hydrogen or alkyl optionally substituted by hydroxy, alkoxy, or alkylthio, R<；2 >；is hydrogen, alkyl, hydroxyalkyl, alkylcarbonyloxyalkyl, alkoxyalkyl, alkylthioalkyl, alkenyl, cycloalkylalkyl, heterocyclylalkyl, aralkyl in which the aryl ring thereof is optionally fused to a 5-membered heterocyclic group or is optionally substituted by one or more substituents selected from alkoxy, amino, alkylamino, dialkylamino, acylamino, halogen, hydroxy, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino or dialkylaminosulfonylamino, R<；3 >；is hydrogen or alkyl optionally substituted by hydroxy, alkoxy, or alkylthio, R<；4 >；is hydrogen or alkyl, R<；5 >；is a quinolinyl, isoquinolinyl or oxodihydroisoquinolinyl group optionally fused to a 5-membered heterocyclic group and optionally substituted by one or more substituents selected from halogen, cyano, hydroxy, alkyl, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkoxy, alkylthio, alkenyl, alkoxycarbonyl, alkynyl, carboxyl, acyl, a group of formula -N(R<；6>；)R<；7>；, aryl optionally substituted by one or more substituents selected from halogen or alkoxy, or heteroaryl having 5 or 6 ring atoms attached through a ring carbon atom to the indicated carbon atom, and R<；6 >；and R<；7 >；are each independently hydrogen or alkyl optionally substituted by hydroxy or alkoxy or one of R<；6 >；and R<；7 >；is hydrogen and the other is acyl, or R<；6 >；and R<；7 >；together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclyl group.
