Ohio State Innovation Foundation;Institute of Molecular Genetics of ASCR, v.v.i.
发明人:
申请号：
EP16847559.8
公开号：
EP3350196A4
申请日:
2016.09.19
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Disclosed herein are compounds comprising dicarba-closo-dodecaborane. The compounds can be, for example, estrogen receptor beta (ERβ) agonists. In some examples, the compounds can be selective ERβ agonists. Also provided herein are methods of treating, preventing, or ameliorating cancer in a subject, suppressing tumor growth in a subject, treating an inflammatory disease in a subject, treating a neurodegenerative disease in a subject, treating a psychotropic disorder in a subject, or a combination thereof by administering to a subject a therapeutically effective amount of one or more of the compounds or compositions described herein, or a pharmaceutically acceptable salt thereof.
