INSTITUTE OF MOLECULAR GENETICS AS CR, V.V.I.;OHIO STATE INNOVATION FOUNDATION
发明人:
TJARKS, WERNER,BARTUNEK, PETR,SEDLAK, DAVID
申请号：
CA2998875
公开号：
CA2998875A1
申请日:
2016.09.19
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Disclosed herein are compounds comprising dicarba-closo-dodecaborane. The compounds can be, for example, estrogen receptor beta (ERß) agonists. In some examples, the compounds can be selective ERß agonists. Also provided herein are methods of treating, preventing, or ameliorating cancer in a subject, suppressing tumor growth in a subject, treating an inflammatory disease in a subject, treating a neurodegenerative disease in a subject, treating a psychotropic disorder in a subject, or a combination thereof, by administering to a subject a therapeutically effective amount of one or more of the compounds or compositions described herein, or a pharmaceutically acceptable salt thereof.
