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Morpholine-Spiro piperidine cyclic amide as ion channel modulators
专利权人:
Vertex Pharmaceuticals Incorporated
发明人:
HADIDA-RUAH, Sara,BINCH, Hayley,DENINNO, Michael,FANNING, Lev,FRIEMAN, Bryan,GROOTENHUIS, Peter,HILGRAF, Nicole,JOSHI, Pramod,KALLEL, Edward,PONTILLO, Joseph,SILINA, Alina,SHETH, Urvi,HURLEY, Dennis,A
申请号:
ES12710841
公开号:
ES2618929T3
申请日:
2012.03.13
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, in which, independently for each case: R1 is C1-C6 alkyl, C1-C6 fluoroalkyl, C3-C8 cycloalkyl, halo, NR8SO2R8, SO2R8 , SR8, SOR8, NR8COR8, NR8CO2R8, CN, CON (R8) 2, SO2N (R8) 2, CF3, heterocycloalkyl, phenyl, heteroaryl, or a straight, branched or cyclic (C1-C8) -R9 chain where up to two CH2 units can be replaced with O, CO, S, SO, SO2, N, CF2, or NR8; R2 is C1-C6 alkyl, C1-C6 alkyl, fluoroalkyl, cycloalkyl, aryl, heteroaryl, or heterocycloalkyl, COR8, CO2R8, CON (R8) 2, CF3, CHF2, or a linear, branched, or cyclic chain (C1-C8 ) -R9 in which up to two CH2 units can be replaced by O, CO, S, SO, SO2, N, CF2, or NR8; R3 is C1-C6 alkyl or halo; R8 is H, C1-C6 alkyl, or C3-C8 cycloalkyl, straight chain, branched or cyclic (C1-C8) -R9 in which up to two CH2 units can be replaced by O, CO, S, SO, SO2, N, CF2, or NR, O2R8 taken together with the atoms to which they are attached form a ring; R9 is H, CF3, CHF2, CH2F, CO2R, OH, aryl, heteroaryl, C3-C8 cycloalkyl, heterocycloalkyl, N (R) 2, NRCOR, CON (R) 2, CN, O SO2R; R is H, C1-C6 alkyl, aryl, heteroaryl, C3-C8 cycloalkyl, or heterocycloalkyl; A is an aryl, heteroaryl or heterocyclic; n is an integer from 1 to 4 inclusive; and o is an integer from 0 to 4 inclusive; wherein each alkyl, fluoroalkyl, cycloalkyl, heterocycloalkyl, phenyl, heteroaryl, C3-C8 cycloalkyl, or aryl from R1 to R8 is substituted ontionally with one or more substituents selected from halo, cyano, oxoalkoxy, hydroxy, amino, nitro, aryl, haloalkyl , and alkyl.Un compuesto de fórmula I:**Fórmula** o una sal farmacéuticamente aceptable del mismo, en la que, independientemente para cada caso: R1 es alquilo C1-C6, fluoroalquilo C1-C6, cicloalquilo C3-C8, halo, NR8SO2R8, SO2R8, SR8, SOR8, NR8COR8, NR8CO2R8, CN, CON(R8)2, SO2N(R8)2, CF3, heterocicloalquilo, fenilo, heteroarilo, o una cadena lineal, ramificada o cíclica (C1-C8)-R9 en donde hasta dos unidades CH2 pueden reemplaz
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