KHARRISON Timoti (GB),ХАРРИСОН Тимоти (GB),TREVITT Grekhem (GB),ТРЕВИТТ Грэхем (GB),KHYUITT Piter Robin (GB),ХЬЮИТТ Питер Робин (GB),O'DOUD Kolin Roderik (GB),О'ДОУД Колин Родерик (GB),BURKAMP Frank (
申请号：
RU2016123363
公开号：
RU0002691105C1
申请日:
2014.12.19
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
FIELD: medicine； pharmaceuticals.SUBSTANCE: invention relates to a novel compound of formula (I) and a pharmaceutically acceptable salt thereof. In formula (I) R1 represents a phenyl group substituted with one or more halogen atoms and optionally a methyl group； R2 and R3 are independently selected from a group consisting of a hydrogen atom, a deuterium atom, a methyl group and a phenyl group； R4 is a hydrogen atom, C1-C6-alkyl group, which is optionally deuterated or substituted with a methoxyphenyl group, a phenyl group optionally substituted with a methyl group, C1-C6-alkylamino-C1-C6-alkyl group, cyclopropyl group or methylpyrazolyl group； or R2 is hydrogen and R4 and R3 and ring atoms, to which they are attached, taken together, form 5-member heterocycloalkyl group； and R5 represents a phenyl group substituted with one or more groups consisting of C1-C6-alkyl group optionally substituted with one or more halogen atoms and hydroxyl group, C1-C6-alkoxy group, optionally substituted with one or more halogen atoms, amino, C1-C6-alkylamino, hydroxy-C1-C6-alkyl group, C1-C4-alkylamino-C1-C6-alkyl group optionally substituted with one or more hydroxyl groups or carbonyl group, an aminosulfonyl group, an alkylimino sulfoxide group, a halogen atom, a cyano group, a pyridinyl group, a pyrazolyl group substituted with a methyl group, a cyclobutyl group, a substituted amino group, 5- to 6-member heterocycloalkyl group, where 5-6 membered heterocycloalkyl group contains in ring 1-2 nitrogen atoms, or a nitrogen atom and an oxygen atom, or a nitrogen atom and a sulfur atom and its dioxide and where 5-6-member heterocycloalkyl group is optionally substituted with one or more C1-C4-alkyl groups optionally substituted with one or more halogen atoms, hydroxy-C1-C4-alkyl group, C1-C4-alkoxy-C1-C4-alkyl group, a halogen atom, hydroxycarbonyl-C1-C4-alkyl group, C3-C4-cycloalkyl group, carbonyl group, substituted C1-C4-alkyl, C0-C4-alkylamino-C1-C4-alkyl group； or R5 represents a p
