TAKAISHI, Mamoru,SATO, Nobuhiro,SHIBUGUCHI, Tomoyuki,MOTOKI, Takafumi,TAKAHASHI, Yoshinori,SASAKI, Takeo,BRAUNTON, Alan
申请号：
ES14756740
公开号：
ES2685025T3
申请日:
2014.02.26
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound represented by the following formula (I) or a pharmaceutically acceptable acid addition salt thereof: ** (See formula) ** wherein R is a hydrogen atom or a C1-6 alkyl group optionally substituted with 1 at 3 fluorine atoms, in which when R is a hydrogen atom, R1 is a chlorine atom, a bromine atom, a trifluoromethyl group, an ethyl group, a trifluoromethoxy group, a methoxy group substituted with a phenyl group, a methoxy group substituted with a C3-8 cycloalkyl group, an ethoxy group optionally substituted with 1 to 3 fluorine atoms, or C3-8 cycloalkyloxy group, R2 is a fluorine atom, a chlorine atom, a methyl group optionally substituted with 2 to 3 fluorine atoms, a methoxy group optionally substituted with 1 to 3 fluorine atoms, or an ethoxy group optionally substituted with 1 to 3 fluorine atoms, R3 is a hydrogen atom or a methyl group, and R4 is an atom of fluorine or a methyl group optionally its substituted with 1 to 3 fluorine atoms, or when R is a C1-6 alkyl group optionally substituted with 1 to 3 fluorine atoms, R1 is a hydrogen atom, a halogen atom, a C1-6 alkyl group optionally substituted with 1 to 3 fluorine atoms, a C1-6 alkoxy group optionally substituted with 1 to 3 substituents selected from a fluorine atom and a C3-8 cycloalkyl group, a C3-8 cycloalkyloxy group, or a 4- to 6-membered heterocycloalkyloxy group , R2 is a hydrogen atom, a cyano group, a halogen atom, a C1-6 alkyl group optionally substituted with 1 to 3 substituents selected from a fluorine atom and a hydroxyl group, or an optionally substituted C1-6 alkoxy group with 1 to 3 substituents selected from a fluorine atom, a C3-8 cycloalkyl group and a 4-6 membered heterocycloalkyl group, R3 is a hydrogen atom or a C1-6 alkyl group, and R4 is a C1- alkyl group 6 optionally substituted with 1 to 3 sel substituents derived from a fluorine atom and a hydroxyl group, or a C1-6 alkoxy group.Un compuesto representado por la siguiente fórmula (I) o una sal de adición de ácido farmacé
