A controlled release oral dosage form comprising a controlled release composition containing amantadine, or salt thereof, wherein the composition provides a controlled release of amantadine, or salt thereof, over a period of 8 hours up to 12 hours, 16 hours, 18 hours, 20 hours or a day, or more than a day, and wherein the controlled release begins within a few minutes after administration or after expiration of a delay period after administration.
