Kodandaram Pillarisetti,Eric Thomas Baldwin,Gordon D. Powers,Rosa Maria Fernandes Cardoso,Ricardo Attar,Francois Gaudet
申请号：
US15237889
公开号：
US10072088B2
申请日:
2016.08.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are antibodies that immunospecifically bind to BCMA. Also described are related polynucleotides capable of encoding the provided BCMA-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments. In addition, methods of using the provided antibodies are described. For example, the provided antibodies may be used to diagnose, treat, or monitor BCMA-expressing cancer progression, regression, or stability to determine whether or not a patient should be treated for cancer or to determine whether or not a subject is afflicted with BCMA-expressing cancer and thus may be amenable to treatment with a BCMA-specific anti-cancer therapeutic, such as the multispecific antibodies against BCMA and CD3 described herein.
