Francois Gaudet,Jennifer F. Nemeth,Ricardo Attar,Benjamin C. Harman,Yingzhe Li,Jinquan Luo,Ronan McDaid,Steven C. Pomerantz,Susan H. Tam,Alexey Teplyakov,John Wheeler,Sheng-Jiun Wu
申请号：
US14844194
公开号：
US09850310B2
申请日:
2015.09.03
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided herein are antibodies that immunospecifically bind to CD123. Also described are related polynucleotides capable of encoding the provided CD123-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments. In addition, methods of using the provided antibodies are described. For example, the provided antibodies may be used to diagnose, treat, or monitor CD123-expressing cancer progression, regression, or stability； to determine whether or not a patient should be treated for cancer； or to determine whether or not a subject is afflicted with CD123-expressing cancer and thus may be amenable to treatment with a CD123-specific anti-cancer therapeutic, such as the multispecific antibodies against CD123 and CD3 described herein.
