GAUDET, Francois,ATTAR, Ricardo,HARMAN, Benjamin C.,LI, Yingzhe,LUO, Jinquan,MCDAID, Ronan,POMERANTZ, Steven C.,TAM, Susan H.,TEPLYAKOV, Alexey,WHEELER, John,WU, Sheng-Jiun,NEMETH, Jennifer F.
申请号：
PH12017500472
公开号：
PH12017500472A1
申请日:
2017.03.13
申请国别(地区):
PH
年份:
2017
代理人:
摘要：
Provided herein are antibodies that immunospecifically bind to CD123. Also described are related polynucleotides capable of encoding the provided CD123-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments. In addition, methods of using the provided antibodies are described. For example, the provided antibodies may be used to diagnose, treat, or monitor CD123-expressing cancer progression, regression, or stability； to determine whether or not a patient should be treated for cancer； or to determine whether or not a subject is afflicted with CD123-expressing cancer and thus may be amenable to treatment with a CD123-specific anti-cancer therapeutic, such as the multispecific antibodies against CD123 and CD3 described herein.
