The present invention provides a kind of Imidazopyrazine SYK inhibitors. In addition, the present invention also provides the pharmaceutical compositions of imidazopyrazine. On the other hand, the present invention provides the methods for the treatment of patient, for the patient with the disease and illness for inhibiting to have response active to Syk, the method includes at least one chemical entity a effective amount of to sick note of the ancient Chinese or symptom for reducing the disease or illness is administered to such patient. In addition, the present invention also provides determine the method that whether there is Syk kinases in sample with what.本發明提供了一種咪唑并哌嗪SYK抑制劑。此外，本發明還提供了咪唑并哌嗪的藥物組合物。另一方面，本發明提供了治療患者的方法，所述患者患有對Syk活性的抑制具有應答的疾病和病症，所述方法包括向這樣的患者給藥對減少所述疾病或病症的病徵或症狀有效量的至少一種化學個體。另外，本發明還提供了用於確定樣品中是否存在Syk激酶的方法。
