Imidazopyrazine SYK inhibitors农业专利-农业学术服务平台

发明人:: 斯科特．A．米切尔,斯科特．A．米切爾,凯文．S．柯里,凱文．S．柯里,彼得．A．布卢姆格林,彼得．A．布盧姆格林,杰弗里．E．克罗普夫,杰弗里．E．克羅普夫,李承勋,李承勛,许建军,許建軍,道格拉斯．G．斯塔福德,詹姆斯．P．哈丁,小安东尼奥．J．巴博萨,小安東尼奧．J．巴博薩,赵仲冬,趙仲冬,戴维．M．阿米斯特德,戴維．M．阿米斯特德,斯科特.A.米切尔,斯科特.A.米切爾,凯文.S.柯里,凱文.S.柯里,彼得.A.布卢姆格林,彼得.A.布盧姆格林,杰弗里.E.克罗普夫,杰弗里.E.克羅普夫,道格拉斯.G.斯塔福德,詹姆斯.P.哈丁,小安东尼奥.J.巴博萨,小安東尼奧.J.巴博薩,戴维.M.阿米斯特德,戴維.M.阿米斯特德

摘要：: The present invention provides Imidazopyrazine SYK inhibitors. The present invention provides specific Imidazopyrazines and its pharmaceutical compositions. The method of patient of the treatment with the inhibition specified disease to react active to Syk and illness is provided, the method includes giving sick note of the ancient Chinese or symptom of a certain amount of pair of this patient mitigation disease or illness effectively at least one chemical entity. It additionally provides and determines Syk kinases whether there is in sample method with what.本發明提供了咪唑并吡嗪SYK抑制劑。本發明提供了特定的咪唑并吡嗪及其藥物組合物。提供了治療患有對Syk活性的抑制起反應的特定疾病和病症的患者的方法，所述方法包括給予這種患者一定量的對減輕所述疾病或病症的病徵或症狀有效的至少一種化學個體。還提供了用於確定樣品中Syk激酶是否存在的方法。