The present invention provides a biocompatible material, such as a guided tissue regeneration membrane (GTR membrane), a guided bone regeneration membrane (GBR membrane), a sheet material, a patch material, or a compensation material, which has a porous structure to allow transportation of the various factors to induce or facilitate the regeneration. The present invention also provides a manufacturing method for the biocompatible material. The present invention forms a biocompatible material from a nano- or microfiber nonwoven fabric fabricated by an electrospinning method, thereby easily producing a porous biocompatible material that allows transportation of the various factors to induce or facilitate the regeneration.