APPLICANT: COLOGENESIS HEALTHCARE PRIVATE LIMITED TITLE: MULTILAYER COLLAGEN GTR MEMBRANE AND METHOD OF PREPARATION THEREOF ABSTRACT The present invention discloses a guided tissue regeneration multilayer collagen membrane exhibiting the property of biocompatibility, cell exclusion, space maintenance, tissue integration, resorbable and ease of use in periodontal regenerative therapy and the like. The present invention further discloses method of preparation of guided tissue regeneration multilayer collagen membrane. The multilayer collagen membrane comprises of a significantly purified collagen membrane with minimum of 2 layers and with at least about 90% by weight of native collagen. The membrane has two distinct surface textures on either side comprising a dense smooth surface for contacting the soft tissue to prevent epithelial down growth and an embossed porous surface for contacting with bone and favoring bone in growth. The multi-layer membrane is formed by adhering atleast two purified collagen membranes through collagen gel and compressing with special equipment to form embossed porous surface on one face and dense smooth surface on opposite face.
