A use of propanamide in the manufacture of a medicine for improving activity of ATP synthesis is disclosed. Propanamide is administered to a subject in need thereof to improve activity of ATP synthesis, decreasing inflammation, reducing accumulation of visceral fat and lowering obesity-induced hyperglycemia.一種丙醯胺之用途,係用以製備提升ATP合成的活性之藥物,係將丙醯胺投予一所需個體,以提升ATP合成的活性、降低發炎反應的發生、減少內臟脂肪的堆積及減低肥胖引起的高血糖現象。