KEITH R FANDRICK,JU GAO,WENJIE LI,Bruce lu,YONGDA ZHANG
申请号：
IN574/DELNP/2011
公开号：
IN2011DN00574A
申请日:
2011.01.25
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
Disclosed are syntheses of 11ß-HSDl inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansens disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).
