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专利权人:
KAREUS THERAPEUTICS; SA.*
发明人:
ISH KHANNA,SIVARAM PILLARISETTI
申请号:
MX2013003078
公开号:
MX2013003078A
申请日:
2011.09.20
申请国别(地区):
MX
年份:
2013
代理人:
摘要:
Novel compounds of Formula I are provided: its stereoisomers and/or pharmaceutically acceptable salts for the treatment of diabetes and diabetes-associated dyslipidemia, wherein R1 is selected from a group consisting of hydroxy, alkoxy, amine, alkyl, haloalkyl, NHSO2R, or NHCOR wherein R is selected from alkyl or cycloalkyl, NHR wherein R is alkyl or cycloalkyl optionally substituted by hydroxy or alkoxy and n1 and n2 are independently selected from 0, 1, and 2. At least one of R3 and R4 and/or R5 and R6 form a cyclic ring of 3-8 carbon atoms optionally containing alkyl groups, hetero atoms, or functional groups such as O, N, SO2. Additionally, when R3 and R4 or R5 and R6 do not form a cyclic ring, then they may be independently selected from hydrogen, alkyl, branched alkyl, and cycloalkyl. L1 is a linear aliphatic chain optionally containing from 4 to 16 carbon atoms. The chain may optionally be substituted one or more times by alkyl, branched alkyl, cycloalkyl, or aryl. R2 is independently selected from hydrogen, alkoxy, hydroxy, alkyl, haloalkyl, cycloalkyl, heterocycloalkyl, heteroaryl, cyano, or COR7, wherein R7 is selected from hydroxy, alkyl, alkoxy, or amine, NHR, NHSO2R, or NHCOR. Y1 is oxygen or hydrogen. Y2 is optional, wherein when Y2 is present, Y1 and Y2 are hydrogen. When Y2 is not present, Y1 is a carbonyl group.Se proporcionan compuestos novedosos de la Fórmula I: sus estereoisómeros y/o sales farmacéuticamente aceptables para el tratamiento de la diabetes y dislipidemia asociada con la diabetes, en donde R1 se selecciona de un grupo que consiste de hidroxi, alcoxi, amina, alquilo, haloalquilo, NHSO2R o NHCOR en donde R se selecciona de alquilo o cicloalquilo, NHR´ en donde R´ es alquilo o cicloalquilo sustituido opcionalmente por hidroxi o alcoxi y n1 y n2 se seleccionan independientemente de 0, 1 y 2. Por lo menos uno de R3 y R4 y/o R5 y R6 forman un anillo cíclico de 3-8 átomos de carbono que contiene opcionalmente grupos alquilo, heteroátomos o
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