Biochemistry reactive materialand device for eliminating low-density lipoprotein (LDL) and method for treating blood or plasma ex vivo to eliminate low-density lipoprotein therein
The present invention provides a biochemistry reactive material, including: a substrate an enzyme compostion immobilize on the substrate, wherein the enzyme compostion is selected from a group consisting of: a first enzyme for eliminating a carbohydrate group of a electronegative low-density lipoprotein (LDL) a second enzyme for eliminating ceramide carried by a electronegative low-density lipoprotein (LDL) and the combination thereof, wherein the biochemistry reactive material is capable of eliminating low-density lipoprotein (LDL).本發明提供一種生化反應材料,包括:一基材;以及一酵素組成物固定於該基材上,其中,該酵素組成物係擇自於由下列所組成之群組:一用以清除陰電性低密度脂蛋白(electronegative low-density lipoprotein,electronegative LDL;簡稱L5)之醣基的第一酵素;一用以清除陰電性低密度脂蛋白之所攜帶之神經醯胺(ceramide)的第二酵素;以及上述之組合,其中該生化反應材料具有去除陰電性低密度脂蛋白的能力。