A method of protecting a liver tissue against injury is disclosed. The method comprises the step of administering to a subject in need thereof a composition comprising a sweet potato trypsin inhibitor (SPTI) in a hepatoprotective amount and a pharmaceutically acceptable carrier, thereby protecting the liver tissue of the subject against injury.本發明揭露一種保護肝組織免於受損傷之方法。該方法包含施用一組合物至需要該組合物之個體的步驟,該組合物包含具可保肝之量的甘藷胰蛋白抑制因子(SPTI)及醫藥上可接受之載體,藉此保護個體之肝組織免於受損傷。