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Process for preparing a medicament
专利权人:
Sean Kee Tee;Xian-Ming Zeng
发明人:
Xian-Ming Zeng,Sean Kee Tee
申请号:
US10594473
公开号:
US09345664B2
申请日:
2004.09.01
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention provides a process for preparing a particulate medicament that has greater homogeneity and a lower adhesion between the particles of the active ingredient and the carrier. The process comprises the steps of: (a) combining a pharmaceutically active ingredient in the form of an agglomerate of primary particles having an agglomerate particle size such that the agglomerate is capable of passing through a sieve having a mesh of 50-3000 μm with a pharmaceutically acceptable particulate carrier, and (b) mixing the resultant material in a mixer to break up the agglomerate into primary particles dispersed in the pharmaceutically acceptable particulate carrier such that 90% or more of the pharmaceutically active ingredient exists as primary particles having a particle size of 50 μm or less.
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