PROBLEM TO BE SOLVED: To provide an optically active cyclic alcohol compound (optically active 4-hydroxy tetrahydroquinoline compound) useful as a synthetic intermediate of a medicinal compound and a method for producing the same.SOLUTION: The method for producing an optically active cyclic alcohol compound is characterized as follows. A cyclic ketone compound represented by general formula [II] is asymmetrically reduced in the presence of (A) an optically active oxazaborolidine compound and a boron hydride compound, or alternatively in the presence of (B) an asymmetric transition metal complex obtained from a transition metal compound and an asymmetric ligand, and a hydrogen donor. In the formula, R denotes a hydrogen atom or a protecting group of an amino group.COPYRIGHT: (C)2012,JPO&INPIT【課題】医薬化合物の合成中間体として有用な光学活性環状アルコール化合物(光学活性4-ヒドロキシテトラヒドロキノリン化合物)及びその製法の提供。【解決手段】一般式[II]:〔式中、Rは水素原子又はアミノ基の保護基を表す。〕で示される環状ケトン化合物を、(A)光学活性オキサザボロリジン類化合物及び水素化ホウ素類化合物の存在下、或いは(B)遷移金属化合物と不斉配位子とから得られる不斉遷移金属錯体と水素供与体との存在下で不斉還元する。【選択図】なし
