The present invention is concerned with aryl-cyclohexyl-tetraazabenzo[e]azulenes of formula Iwherein R1, R2 and R3 are as described herein.The compounds according to the invention act as V1a receptor modulators, and in particular as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful as therapeutics acting peripherally and centrally in the conditions of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior.本發明係關於式I之芳基-環己基-四氮雜苯并[e]薁其中R1、R2及R3係如本文所述。本發明之化合物扮演V1a受體調節劑、且尤其作為V1a受體拮抗劑。本發明亦係關於其製造、含有其之醫藥組合物及其作為藥劑之用途。本發明之活性化合物可作為周邊及中樞起作用之治療劑用於以下病況中:痛經、男性或女性性功能障礙、高血壓、慢性心臟衰竭、血管升壓素分泌不當、肝硬化、腎病症候群、焦慮症、憂鬱症、強迫症、泛自閉症障礙、精神分裂症及攻擊性行為。
