INSULINE MODIFIÉE PAR UN INHIBITEUR DE TRANSPORTEUR DE GLUCOSE POUR L'ADMINISTRATION D'INSULINE SENSIBLE AU GLUCOSE

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专利权人:

North Carolina State University

发明人:

申请号：

EP18866288.6

公开号：

EP3694539A1

申请日:

2018.10.10

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

Disclosed herein is a glucose-responsive insulin delivery system based on the interaction between the glucose-modified insulin and glucose transporters (GLUTs) on erythrocytes (or red blood cells, RBCs). After being conjugated with a competitive inhibitor of a glucose transporter, insulin can efficiently bind to RBC membranes. The binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of blood glucose (BG) level in vivo.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/