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GLUCOSE TRANSPORTER INHIBITOR-MODIFIED INSULIN FOR GLUCOSE-RESPONSIVE INSULIN DELIVERY
专利权人:
NORTH CAROLINA STATE UNIVERSITY
发明人:
Zhen GU,Jinqiang WANG
申请号:
US16755183
公开号:
US20200239538A1
申请日:
2018.10.10
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Disclosed herein is a glucose-responsive insulin delivery system based on the interaction between the glucose-modified insulin and glucose transporters (GLUTs) on erythrocytes (or red blood cells, RBCs). After being conjugated with a competitive inhibitor of a glucose transporter, insulin can efficiently bind to RBC membranes. The binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of blood glucose (BG) level in vivo.
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中国工程科技知识中心
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