THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY;CITY OF HOPE;AUM LIFE TECH, INC.
发明人:
John J. Rossi,Masad J. Damha,Veenu Aishwarya,Mayumi Takahashi,Haitang Li
申请号：
US16335663
公开号：
US20200030361A1
申请日:
2017.09.23
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The disclosure relates to synthetic oligonucleotides that bind at least a portion of a dimerization initiation site (DIS) of a retrovirus genomic ribonucleic acid (RNA) molecule. In some aspects, the synthetic oligonucleotides include a 2-deoxy-2-fluoroarabinonucleotide (2-FANA)-modified nucleotide sequence. In some embodiments, the 2-FANA-modified nucleotide sequence inhibits dimerization of retroviral genomes (e.g., an HIV genome). Other embodiments include methods of inhibiting expression of a retrovirus using the synthetic oligonucleotide, and methods of treating or preventing a retroviral infection.
