PYRIMIDO-ISOQUINOLIN-QUINONE DERIVATIVE COMPOUNDS, AND PHARMACEUTICALLY ACCEPTABLE SALTS, ISOMERS AND TAUTOMERS THEREOF； PHARMACEUTICAL COMPOSITION； PREPARATION METHOD； AND USE THEREOF IN THE TREATMENT OF DISEASES CAUSED BY BACTERIA AND MULTIDRUG-RESISTANT BACTERIA
David Reinaldo Vásquez Velásquez,Juan Andrés Andrades Lagos,Javier Andrés Campanini Salinas
申请号：
US16067033
公开号：
US20190367505A1
申请日:
2016.12.29
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides pyrimidine-isoquinolin-quinone derivatives of formula I, their salts, isomers, pharmaceutically acceptable tautomers； pharmaceutical composition； preparation procedure； and their use in the treatment of bacterial and resistant bacterial diseases, such as methicillin-resistant Staphylococcus aureus (MRSA), intermediate vancomycin-resistant Staphylococcus aureus (VISA), vancomycin-resistant Staphylococcus aureus (VRSA), vancomycin-resistant Enterococcus spp. (VRE), Enterococcus faecalis, Emerging Staphylococcus aureus with resistance to linezolid and/or bacterial strains not susceptible to daptomycin.Where the radicals R1, R2, R3, R4 and R5 are as defined in the work specifications of the present invention.
