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COMPOSÉS DÉRIVÉS PYRIMIDO-ISOQUINOLINE-QUINONES, LEURS SELS, ISOMÈRES, TAUTOMÈRES PHARCEUTIQUEMENT ACCEPTABLES, COMPOSITION PHARMACEUTIQUE, PROCÉDÉ DE PRÉPARATION, ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES BACTÉRIENNES ET D'INFECTIONS À BACTÉRIES MULTIRÉSISTANTES
专利权人:
Universidad De Chile
发明人:
申请号:
EP16880235.3
公开号:
EP3404026A1
申请日:
2016.12.29
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention provides pyrimidine-isoquinolin-quinone derivatives of formula I, their salts, isomers, pharmaceutically acceptable tautomers; pharmaceutical composition; preparation procedure; and their use in the treatment of bacterial and resistant bacterial diseases, such as methicillin-resistant Staphylococcus aureus (MRSA), intermediate vancomycin-resistant Staphylococcus aureus (VISA), vancomycin-resistant Staphylococcus aureus (VRSA), vancomycin-resistant Enterococcus spp. (VRE), Enterococcus faecalis, Emerging Staphylococcus aureus with resistance to linezolid and/or bacterial strains not susceptible to daptomycin.Where the radicals R1, R2, R3, R4 and R5 are as defined in the work specifications of the present invention.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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