COMPOSÉS DÉRIVÉS PYRIMIDO-ISOQUINOLINE-QUINONES, LEURS SELS, ISOMÈRES, TAUTOMÈRES PHARCEUTIQUEMENT ACCEPTABLES, COMPOSITION PHARMACEUTIQUE, PROCÉDÉ DE PRÉPARATION, ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES BACTÉRIENNES ET D'INFECTIONS À BACTÉRIES MULTIRÉSISTANTES
The present invention provides pyrimidine-isoquinolin-quinone derivatives of formula I, their salts, isomers, pharmaceutically acceptable tautomers； pharmaceutical composition； preparation procedure； and their use in the treatment of bacterial and resistant bacterial diseases, such as methicillin-resistant Staphylococcus aureus (MRSA), intermediate vancomycin-resistant Staphylococcus aureus (VISA), vancomycin-resistant Staphylococcus aureus (VRSA), vancomycin-resistant Enterococcus spp. (VRE), Enterococcus faecalis, Emerging Staphylococcus aureus with resistance to linezolid and/or bacterial strains not susceptible to daptomycin.Where the radicals R1, R2, R3, R4 and R5 are as defined in the work specifications of the present invention.
