COMPOSÉS DÉRIVÉS PYRIMIDO-ISOQUINOLINE-QUINONES, LEURS SELS, ISOMÈRES, TAUTOMÈRES PHARCEUTIQUEMENT ACCEPTABLES, COMPOSITION PHARMACEUTIQUE, PROCÉDÉ DE PRÉPARATION, ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES BACTÉRIENNES ET D'INFECTIONS À BACTÉRIES MULTIRÉSISTANTES
VÁSQUEZ VELÁSQUEZ, David Reinaldo,ANDRADES LAGOS, Juan Andrés,CAMPANINI SALINAS, Javier Andrés
申请号：
EP16880235
公开号：
EP3404026A4
申请日:
2016.12.29
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The present invention provides pyrimidine-isoquinolin-quinone derivatives of formula I, their salts, isomers, pharmaceutically acceptable tautomers； pharmaceutical composition； preparation procedure； and their use in the treatment of bacterial and resistant bacterial diseases, such as methicillin-resistant Staphylococcus aureus (MRSA), intermediate vancomycin-resistant Staphylococcus aureus (VISA), vancomycin-resistant Staphylococcus aureus (VRSA), vancomycin-resistant Enterococcus spp. (VRE), Enterococcus faecalis, Emerging Staphylococcus aureus with resistance to linezolid and/or bacterial strains not susceptible to daptomycin. Where the radicals R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the work specifications of the present invention.
