BUDZIK, BRIAN,布莱恩,布萊恩,COOPER, DAVID GWYN,寇大伟,寇大偉,FORBES, IAN THOMSON,冯艾恩,馮艾恩,GARZYA, VINCENZO,文森洛,JIN,JIAN,金坚,金堅,SHI, DONGCHUAN,史东川,史東川,SMITH, PAUL WILLIAM,史保罗,史保羅,WALKER, GRAHAM,魏克瀚
申请号：
TW095135887
公开号：
TWI389905B
申请日:
2006.09.28
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
Compounds of formula (I) and salts and solvates are provided:wherein R4is fluoro, R5is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1－6alkoxy substituted with one or more fluorine atoms； and R6is selected from halogen, cyano, C1-6alkyl,C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.本發明提供式(I)化合物及鹽類及溶劑化物：其中R4是氟,R5是選自氫、鹵基、氰基、C1－6烷基、經一或多個氟原子取代之C1－6烷基、C1－6烷氧基及經一或多個氟原子取代之C1－6烷氧基；且R6是選自鹵基、氰基、C1－6烷基、經一或多個氟原子取代之C1－6烷基、C3－6環烷基、經一或多個氟原子取代之C3－6環烷基、C1－6烷氧基及經一或多個氟原子取代之C1－6烷氧基,且Q是氫或C1－6烷基。該化合物預期是可用於醫療,例如治療精神性障礙及辨識受損。
