CREARE, INCORPORATED;THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION; DEPARTMENT OF HEALTH AND HUMAN SERVICES; CENTERS FOR DISEASE CONTROL AND PREVENTION
发明人:
PAPANIA, MARK J.,BARRY, JAMES J.,BAGLEY, MARK C.,NORRIS, JAMES,KNAUS, DARIN A.,FRIETS, ERIC M.
申请号：
CA2908158
公开号：
CA2908158A1
申请日:
2014.04.03
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
A nasal delivery device (10) includes a nasal prong (14) and an activation member (22). The nasal prong can comprise an opening (16) at a top and bottom portion (18) of the prong to allow for the passage of an aerosolized treatment agent (30) through the nasal prong. The activation member can be positioned on the nasal delivery device at a location that is spaced apart from the subject's oral cavity when the nasal prong is received into the nostril (32, 38) of the subject. The activation member can be configured to detect a desired exhalation state of the subject and upon detection of the desired exhalation state, the activation member activates the delivery of the aerosolized treatment agent. The nasal delivery device comprises a handpiece (20) that can be held by a user and having an activation member for triggering the delivery of the treatment agent to a subject, and an intranasal portion or nose prong extending from the handpiece and having a dose container receiving area (58, 72) and an aerosolizing member (54, 56) to aerosolize the agent and eject an aerosolized plume into a nare of the subject. The device may comprise a vibrating-mesh nebulizer (510, 530) at a distal end of the device extending into a nare of the subject. The device may comprise an alignment device (214, 220) for improving alignment of the device with a subject to increase delivery and deposition of the agent.
