Tetrahidroisoquinolina substituted Compounds, inhibitors of the coagulation factor XIa (fxia)； Pharmaceutical composition that comprises； and its use for the treatment of an inflammatory or selected thromboembolic disorder of unstable angina, Acute Coronary Syndrome and fibrillation On atrial, among others.
ORWAT, MICHAEL J.,PINTO, DONALD J.P.,SMITH II, LEON M.,SRIVASTAVA, SHEFALI
申请号：
CL2014000925
公开号：
CL2014000925A1
申请日:
2014.04.11
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.COMPUESTOS DERIVADOS DE TETRAHIDROISOQUINOLINA SUSTITUIDOS, INHIBIDORES DEL FACTOR DE COAGULACION XIA (FXIA)； COMPOSICION FARMACEUTICA QUE LOS COMPRENDE； Y SU USO PARA EL TRATAMIENTO DE UN TRASTORNO TROMBOEMBOLICO O INFLAMATORIO SELECCIONADO DE ANGINA INESTABLE, SINDROME CORONARIO AGUDO Y FIBRILACION ATRIAL, ENTRE OTROS.
