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METHOD AND PHARMACEUTICAL COMPOSITION FOR TREATMENT OF ALZHEIMER'S DISEASE AND DISORDERS, DISORDERS OR MEMORY LOSS
专利权人:
МАССАЧУСЕТС ИНСТИТЬЮТ ОФ ТЕКНОЛОДЖИ (US)
发明人:
ВЁРТМАН Ричард Дж. (US),РИЧАРДСОН Ингрид (US)
申请号:
RU2011120440/15
公开号:
RU2011120440A
申请日:
2011.05.20
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A method of treating an object with Alzheimer's disease, treating memory impairment or memory loss in an object, comprising administering to the object a pharmaceutical composition comprising (a) omega-3 fatty acid, omega-6 fatty acid, or a combination thereof; (b) uridine, its acyl derivative, uridine phosphate or cytidine 5'-diphosphocholine (CDP-choline) and (c) choline, its metabolic precursor or salt of choline. 2. The method of claim 1, wherein the omega-3 fatty acid is docosahexaenoic acid, eicosapentaenoic acid, docosapentaenoic acid or alpha-linolenic acid. The method according to claim 1, wherein the omega-6 fatty acid is arachidonic acid or linolenic acid. The method of claim 1, wherein the polyunsaturated fatty acid enhances the synthesis of a phospholipid in an object’s brain cell. The method according to claim 4, wherein the phospholipid is phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine or sphingomyelin. The method according to claim 1, wherein the uridine is an acyl derivative of uridine, uridine phosphate or cytidine 5'-diphosphocholine (CDP-choline). The method according to claim 6, wherein the uridine phosphate is uridine-5'-monophosphate (UMF), uridine-5'-diphosphate (UDF), uridine-5'-triphosphate (UTF) or a salt of UMF, UDF or UTF. . The method of claim 6, wherein the uridine phosphate is uridine-5'-monophosphate (UMF). The method of claim 1, wherein the choline salt is choline chloride, choline bitartrate or choline stearate. The method according to claim 1, wherein the composition comprises from about 200 to about 800 mg of uridine, its acyl derivative, uridine phosphate or CDP-choline. The method according to claim 1, in which the composition contains from about 200 mg to about 800 mg x1. Способ лечения объекта с болезнью Альцгеймера, лечения нарушения памяти или потери памяти у объекта, включающий введение объекту фармацевтической композиции, содержащей (а) омега-3 жирную кислоту, омега-6 жирную кис
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